Arch Iran Med
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Many genes with different inheritance modes contribute to the pathogenicity of intellectual disability (ID) making it the most known genetically heterogeneous disorder. Advanced next-generation sequencing (NGS) technologies have helped researchers identify genes underlying ID at an exponential pace. As a consanguineous country, Iran is a hotspot for discovering novel autosomal recessive intellectual disability (ARID) genes. ⋯ Functional studies have been performed on 29% of the genes identified in Iran. More than one affected family has been reported for many of these genes, supporting their causative role in ID pathogenesis. Despite the notable contribution of Iran in gene-discovery research, further functional studies on the identified genes are required.
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Mental disorders contribute significantly to the burden of diseases in Iran. Therefore, the current study aims to assess the prevalence of psychiatric disorders and their associated factors among youth in Kermanshah province of Iran. ⋯ Based on the results of the current study, it can be concluded that the prevalence of mental and psychiatric disorders among the youth in Ravansar district, western Iran is relatively high and needs specific plans and interventions to control it.
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Observational Study
Multiple Sclerosis in Tehran: Rising Prevalence alongside Stabilizing Incidence - True Increase or Enhanced Diagnosis?
Multiple sclerosis (MS) is a chronic and potentially progressive demyelinating disease of the central nervous system. The incidence and prevalence rate of the disease has been increasing globally, especially in females. ⋯ Tehran is among MS high-risk areas with increasing trends in prevalence and increasing followed by plateaued incidence rates indicating necessity of extra investigations of the underlying reasons and health system preparedness for further health care requirements of MS patients.