Arch Med Sci
-
Hepatic malignancy is one of the most common malignant neoplasms around the globe, and hepatocellular carcinoma (HCC) is the most common type. In this study, the roles and mechanisms of MiRNA-610 in the chemo resistance of HCC will be discussed. ⋯ MiRNA-610 not only played a tumour suppressor role in HCC but also affected chemo resistance to DDP. This role is mainly mediated through targeted silencing of the HDGF gene, which may offer a new potential therapeutic target and improve the clinical therapeutic effect for HCC.
-
Sulodexide (SDX), a heparinoid used to treat vascular diseases, exerts anti-ischemic properties. However, the underlying molecular mechanisms remain unclear. Induction of glutathione (GSH)-dependent genes protects against ischemia. Here, we investigated the effect of SDX on GSH-associated gene expression in human umbilical endothelial cells (HUVECs) using an in vitro ischemia model. ⋯ Our studies provide the first evidence that SDX activates GSH-related genes in OGD-injured HUVECs.
-
In the context of the global tuberculosis (TB) burden, children represent 10% of all cases, with high incidence rates still reported by many regions worldwide. The study aim was to determine whether there is a correlation between TB clinical diagnosis and low birth weight in children at various ages. ⋯ The correlation between clinical diagnosis of tuberculosis in children at various ages and their low birth weight was positive but was not statistically significant. However, this research hypothesis should be tested in further studies on larger population groups, due to the current public health context of "End TB", promoted worldwide.
-
The purpose of this study was to introduce a measure of patient's burden based on Elixhauser's comorbidity index. The mentioned measure needed to be based solely on administrative data and be applicable to all specialisations of hospital treatment. Moreover, the intention was to validate the estimation power of the models based on the groups of hospitalisations which were similar with respect to the primary diagnosis. ⋯ Our results support the hypothesis that comorbidity properly describes mortality in homogeneous groups of patients. Our models could be condensed into one, uniform, single-number comorbidity scale that summarizes all of the patient's burden. It was found that the odds ratio of some variables differed between homogeneous groups.
-
The aim of this study was to analyse the incidences of hypopituitarism before and after surgical resection of sellar tumours and to find the factors related to the incidences. ⋯ To sum up, we found that the postoperative incidences of hypopituitarism were higher than the preoperative incidences. Tumour type, surgery resection methods, and tumour sizes were important contributing factors to the incidence of postoperative hypogonadism.