Arch Med Sci
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Blood lipoprotein(a) (Lp(a)) levels have been observed to be inversely correlated with type 2 diabetes (T2D). In this Mendelian randomization (MR) study, the causal impact of genetically predicted Lp(a) on T2D was assessed. ⋯ Genetically predicted Lp(a) concentration does not appear to be causally related to the risk of T2D.
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Sjögren's syndrome (SS) and rheumatoid arthritis (RA) are two chronic autoimmune diseases. To date, there have been few reports on the overlap between SS and RA in China, especially regarding correlated acute renal failure cases. ⋯ We also provide a relevant analysis of SS and RA overlap syndrome treatment.
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Ferritin has been implicated in body physiology and pathology. Smoking cigarettes (Cg) alters ferritin metabolism. Waterpipe (Wp) smoking has recently reemerged as a global epidemic and is linked to the most devastating diseases. However, the effect of smoking Wp on ferritin is not known. Therefore, the current study compared plasma ferritin in adolescents smoking Cg, Wp, both (CgWp) versus never smoked. ⋯ The results indicate that ferritin is elevated in adolescent smokers, particularly the boys smoking Wp and CgWp and in the girls smoking Cg and CgWp.
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Our aim was to analyze the regional and national levels of the global burden of rheumatoid arthritis (RA) among young adults (aged 15-49) in order to identify long-term trends. ⋯ From 1990 to 2019, there was a notable increase in both the age-standardized DALY rates and ASIRs associated with RA in young adults. This positive trend was particularly evident in high-SDI regions. However, it is worth noting that the impact of RA on young adults in low-income areas of Andean Latin America was also substantial.
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Accumulating evidence has proved that long non-coding RNAs (lncRNAs) are involved in progression of glioma. Nevertheless, the role of TUBA4B in glioma remains unclear. ⋯ This study revealed for the first time that TUBA4B could be a tumor suppressor gene in glioma by adjustment of the TUBA4B/miR-183/SMAD4 axis, which may provide a useful prognostic biomarker and promising therapeutic target for glioma treatment.