Clin Med
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Case Reports
A diagnostic dilemma: differentiating between granulomatosis with polyangiitis and tuberculosis.
Granulomatosis with polyangiitis (GPA, formerly Wegener's granulomatosis) can present diagnostic difficulties for the clinician as there can be considerable overlap in features with tuberculosis (TB). Indeed, there are documented cases both of coexisting TB and GPA, and cases wrongly diagnosed as GPA when in fact TB was the underlying diagnosis. This lesson presents a case of GPA where TB was also considered as a differential and highlights the diagnostic and management difficulties when this is the case.
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The majority of physicians work a weekly timetable consisting of programmed activities (PAs) defined by the consultant contract. This paper describes the implementation of an annualised contract within a gastroenterology department, which is located across two district general hospital sites within the same trust. The perceived benefits of the system include the introduction of a new out-of-hours emergency endoscopy service, more efficient backfilling of vacant endoscopy lists and greater transparency of work patterns and workload between colleagues and within the trust.
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The management of patients with hypercalcaemia should be informed by the patient's symptoms and signs, by the degree of elevation of calcium, by the underlying mechanism by which calcium has been elevated and by the disease process underlying the presentation. Regardless of diagnosis, all significantly hypercalcaemic patients should be rendered euvolaemic before any further and more specific treatment is considered. Highly symptomatic patients and those with a calcium level of > 3.5 mmol represent a medical emergency that requires inpatient treatment.