Cochrane Db Syst Rev
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Cochrane Db Syst Rev · Jan 2000
ReviewAldose reductase inhibitors for the prevention and treatment of diabetic peripheral neuropathy.
To assess the efficacy of aldose reductase inhibitors in the prevention, reversal or delay in the progression of diabetic peripheral neuropathy. ⋯ Although aldose reductase inhibitor treatment has been demonstrated to diminsh the reduction in motor nerve conduction velocity, the clinical relevance of such a change in this outcome measure is uncertain. There was no effect in terms of this outcome measure in the smaller sensory fibres, degeneration of which is primarily responsible for the most common neuropathic syndrome associated with diabetes, that of severe pain and loss of sensation in the extremity leading in some cases to ulceration and eventual amputation.
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Cochrane Db Syst Rev · Jan 2000
ReviewFurosemide for symptomatic patent ductus arteriosus in indomethacin-treated infants.
Inhibition of prostaglandin synthesis mediates closure of the ductus arteriosus and renal side effects after indomethacin administration. Because furosemide increases prostaglandin production, it could potentially help prevent indomethacin-related toxicity but also decrease ductal response to indomethacin. ⋯ There is not enough evidence to support the administration of furosemide to premature infants treated with indomethacin for symptomatic patent ductus arteriosus. Furosemide appears to be contraindicated in the presence of dehydration in those infants.
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Traveller's diarrhoea is a syndrome frequently encountered in persons crossing an international boundary. Diarrhoea can lead to significant discomfort and interference with travel plans. Bacterial pathogens are a frequent cause of this syndrome. Several antibiotics have been tested for efficacy in reducing the duration and severity of the illness. ⋯ Antibiotic treatment is associated with shorter duration of diarrhoea but higher incidence of side-effects. Trials generally do not report duration of post-treatment diarrhoea using time-to-event analyses, and should do.
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Cochrane Db Syst Rev · Jan 2000
ReviewFollicle-stimulating hormone and human menopausal gonadotropin for ovarian stimulation in assisted reproduction cycles.
To conduct a systematic overview of available data comparing FSH and hMG in IVF treatment cycles. ⋯ This meta-analysis demonstrates that in IVF cycles the use of FSH is associated with a significantly higher clinical pregnancy rate than hMG.
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Cochrane Db Syst Rev · Jan 2000
ReviewMaternal oxygen administration for suspected impaired fetal growth.
Fetal hypoxaemia is often a feature of fetal growth impairment. It has been suggested that perinatal outcome after suspected impaired fetal growth might be improved by giving mothers continuous oxygen until delivery. ⋯ There is not enough evidence to evaluate the benefits and risks of maternal oxygen therapy for suspected impaired fetal growth.