Cochrane Db Syst Rev
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Cochrane Db Syst Rev · Jan 2000
ReviewNewer atypical antipsychotic medication versus clozapine for schizophrenia.
Clozapine is an atypical antipsychotic drug, which is claimed to have superior efficacy and to cause fewer movement disorders. However, clozapine carries a significant risk of serious blood disorders. Newer atypical antipsychotics are safer alternatives that might share the benefits of clozapine. It is thus of interest to compare the effectiveness of newer atypical antipsychotics with the effectiveness of clozapine. ⋯ The equal effectiveness and tolerability of new atypical drugs in comparison with clozapine is not yet demonstrated. Lack of statistical power to determine the comparative efficacy and effectiveness of newer atypical drugs makes it difficult to judge whether newer drugs are more effective, less effective or equivalent. Trials of sufficient power, with longer duration, measuring clinically important outcomes, are needed to assess the true comparative clinical effectiveness, tolerability and cost effectiveness of newer drugs in relation to clozapine.
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Circulating progesterone may be the cause of slower gastrointestinal movement in mid and late pregnancy. ⋯ Dietary supplements of fibre in the form of bran or wheat fibre are likely to help women experiencing constipation in pregnancy.
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Cochrane Db Syst Rev · Jan 2000
ReviewFollicle-stimulating hormone and human menopausal gonadotropin for ovarian stimulation in assisted reproduction cycles.
To conduct a systematic overview of available data comparing FSH and hMG in IVF treatment cycles. ⋯ This meta-analysis demonstrates that in IVF cycles the use of FSH is associated with a significantly higher clinical pregnancy rate than hMG.
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Cochrane Db Syst Rev · Jan 2000
ReviewMaternal oxygen administration for suspected impaired fetal growth.
Fetal hypoxaemia is often a feature of fetal growth impairment. It has been suggested that perinatal outcome after suspected impaired fetal growth might be improved by giving mothers continuous oxygen until delivery. ⋯ There is not enough evidence to evaluate the benefits and risks of maternal oxygen therapy for suspected impaired fetal growth.
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Cochrane Db Syst Rev · Jan 2000
ReviewGeneral versus spinal/epidural anaesthesia for surgery for hip fractures in adults.
The majority of hip fracture patients are treated surgically, requiring anaesthesia. ⋯ Regional anaesthesia and general anaesthesia appear to produce comparable results for most of the outcomes studied. Regional anaesthesia may reduce short-term mortality but no conclusions can be drawn for longer term mortality.