Cochrane Db Syst Rev
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Cochrane Db Syst Rev · Apr 2014
ReviewWITHDRAWN: Preventive staff-support interventions for health workers.
This review was merged with the review titled: Preventing occupational stress in healthcare workers because of major overlap between the two. The editorial group responsible for this previously published document have withdrawn it from publication.
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Cochrane Db Syst Rev · Apr 2014
Review Meta AnalysisFixed-dose combination therapy for the prevention of cardiovascular disease.
Cardiovascular disease (CVD) is the leading cause of death and disability worldwide, yet CVD risk factor control and secondary prevention rates remain low. A fixed-dose combination of blood pressure and cholesterol lowering and antiplatelet treatments into a single pill, or polypill, has been proposed as one strategy to reduce the global burden of CVD by up to 80% given its potential for better adherence and lower costs. ⋯ Compared with placebo, single drug active component, or usual care, the effects of fixed-dose combination therapy on all-cause mortality or CVD events are uncertain; only few trials report these outcomes and the included trials were primarily designed to observe changes in CVD risk factor levels rather than clinical events. Reductions in blood pressure and lipid parameters are generally lower than those previously projected, though substantial heterogeneity of results exists. Fixed-dose combination therapy is associated with modest increases in adverse events compared with placebo, single drug active component, or usual care but may be associated with improved adherence to a multidrug regimen. Ongoing trials of fixed-dose combination therapy will likely inform key outcomes.
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Cochrane Db Syst Rev · Apr 2014
Review Meta AnalysisInterventions for iatrogenic inferior alveolar and lingual nerve injury.
Iatrogenic injury of the inferior alveolar or lingual nerve or both is a known complication of oral and maxillofacial surgery procedures. Injury to these two branches of the mandibular division of the trigeminal nerve may result in altered sensation associated with the ipsilateral lower lip or tongue or both and may include anaesthesia, paraesthesia, dysaesthesia, hyperalgesia, allodynia, hypoaesthesia and hyperaesthesia. Injury to the lingual nerve may also affect taste perception on the affected side of the tongue. The vast majority (approximately 90%) of these injuries are temporary in nature and resolve within eight weeks. However, if the injury persists beyond six months it is deemed to be permanent. Surgical, medical and psychological techniques have been used as a treatment for such injuries, though at present there is no consensus on the preferred intervention, or the timing of the intervention. ⋯ There is clearly a need for randomised controlled clinical trials to investigate the effectiveness of surgical, medical and psychological interventions for iatrogenic inferior alveolar and lingual nerve injuries. Primary outcomes of this research should include: patient-focused morbidity measures including altered sensation and pain, pain, quantitative sensory testing and the effects of delayed treatment.
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Cochrane Db Syst Rev · Apr 2014
ReviewWITHDRAWN: Psychosocial treatment for opiate abuse and dependence.
The review has been withdrawn from publication because it is out of date and the authors are currently not available for updating it The editorial group responsible for this previously published document have withdrawn it from publication.