Cochrane Db Syst Rev
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Cochrane Db Syst Rev · Jun 2015
Review Meta AnalysisWITHDRAWN: Topical negative pressure for treating chronic wounds.
This review has been split into three reviews each addressing a single wound type (pressure ulcers, venous leg ulcers and foot ulcers in people with diabetes). Protocols have been published. Two reviews have been published: Negative pressure wound therapy for treating foot wounds in people with diabetes mellitus. ⋯ The third review, Negative pressure wound therapy for treating leg ulcers, will be published in 2015. The original parent review ‐ Topical negative pressure for treating chronic wounds ‐ is being withdrawn. The editorial group responsible for this previously published document have withdrawn it from publication.
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Social skills programmes (SSP) are treatment strategies aimed at enhancing the social performance and reducing the distress and difficulty experienced by people with a diagnosis of schizophrenia and can be incorporated as part of the rehabilitation package for people with schizophrenia. ⋯ Compared to standard care, social skills training may improve the social skills of people with schizophrenia and reduce relapse rates, but at present, the evidence is very limited with data rated as very low quality. When social skills training was compared to discussion there was no difference on patients outcomes. Cultural differences might limit the applicability of the current results, as most reported studies were conducted in China. Whether social skills training can improve social functioning of people with schizophrenia in different settings remains unclear and should be investigated in a large multi-centre randomised controlled trial.
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Cochrane Db Syst Rev · Jun 2015
ReviewAntifibrinolytic amino acids for upper gastrointestinal bleeding in people with acute or chronic liver disease.
Upper gastrointestinal bleeding is one of the most frequent causes of morbidity and mortality in the course of liver cirrhosis. People with liver disease frequently have haemostatic abnormalities such as hyperfibrinolysis. Therefore, antifibrinolytic amino acids have been proposed to be used as supplementary interventions alongside any of the primary treatments for upper gastrointestinal bleeding in people with liver diseases. This is an update of this Cochrane review. ⋯ This updated Cochrane review identified no randomised clinical trials assessing the benefits and harms of antifibrinolytic amino acids for upper gastrointestinal bleeding in people with acute or chronic liver disease. The benefits and harms of antifibrinolytic amino acids need to be tested in randomised clinical trials. Unless randomised clinical trials are conducted to assess the trade-off between benefits and harms, we cannot recommend or refute antifibrinolytic amino acids for upper gastrointestinal bleeding in people with acute or chronic liver diseases.
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Cochrane Db Syst Rev · Jun 2015
ReviewSnake antivenom for snake venom induced consumption coagulopathy.
Snake venom induced consumption coagulopathy is a major systemic effect of envenoming. Observational studies suggest that antivenom improves outcomes for venom induced consumption coagulopathy in some snakebites and not others. However, the effectiveness of snake antivenom in all cases of venom induced consumption coagulopathy is controversial. ⋯ Randomised placebo-controlled trials are required to investigate the effectiveness of snake antivenom for clinically relevant outcomes in patients with venom induced consumption coagulopathy resulting from snake bite. Although ethically difficult, the routine administration of a treatment that has a significant risk of anaphylaxis cannot continue without strong evidence of benefit.
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Cochrane Db Syst Rev · Jun 2015
ReviewEffects of restricted caffeine intake by mother on fetal, neonatal and pregnancy outcomes.
Maternal caffeine consumption during pregnancy may have adverse effects on fetal, neonatal and maternal outcomes. ⋯ There is insufficient evidence to confirm or refute the effectiveness of caffeine avoidance on birthweight or other pregnancy outcomes. There is a need to conduct high-quality, double-blinded RCTs to determine whether caffeine has any effect on pregnancy outcome.