Cochrane Db Syst Rev
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Cochrane Db Syst Rev · Dec 2021
ReviewIntravenous thrombolytic treatment and endovascular thrombectomy for ischaemic wake-up stroke.
About one in five strokes occur during sleep (wake-up stroke). People with wake-up strokes have previously been considered to be ineligible for thrombolytic treatment because the time of stroke onset is unknown. However, recent studies suggest benefit from recanalisation therapies in selected patients. ⋯ In selected patients with acute ischaemic wake-up stroke, both intravenous thrombolytic treatment and endovascular thrombectomy of large vessel occlusion improved functional outcome without increasing the risk of death. However, a possible increased risk of symptomatic intracranial haemorrhage associated with thrombolytic treatment cannot be ruled out. The criteria used for selecting patients to treatment differed between the trials. All studies were relatively small, and six of the seven studies were terminated early. More studies are warranted in order to determine the optimal criteria for selecting patients for treatment.
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Cochrane Db Syst Rev · Dec 2021
ReviewParenteral versus enteral fluid therapy for children hospitalised with bronchiolitis.
The main focus of treatment for children hospitalised with bronchiolitis is supportive, including oxygen supplementation, respiratory support, and fluid therapy. Up to half of infants hospitalised with bronchiolitis require non-oral fluid therapy due to dehydration or concerns related to the safety of oral feeding. The two main modalities used for non-oral fluid therapy are parenteral (intravenous (IV)) and enteral tube (nasogastric (NG) or orogastric (OG)). However, it is not known which mode is optimal in young children. ⋯ Based on two RCTs, enteral tube feeding likely results in little to no difference in length of hospital stay compared with the IV fluid group. However, enteral tube fluid therapy likely results in a large increase in the success of insertion of fluid modality at first attempt, and a large reduction in change in modality of fluid therapy. It also probably reduces local complications compared to the IV fluid group. Despite bronchiolitis being one of the most prevalent childhood conditions, we identified only two studies with under 1000 participants in total, which highlights the need for multicentre trials. Future studies should explore type of fluid administered, parent-reported outcomes and preferences, and the role of shared decision-making.
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Cochrane Db Syst Rev · Nov 2021
ReviewInterventions for smoking cessation in Indigenous populations.
This review has been withdrawn because it does it does not include recent evidence and does not reflect up-to-date Cochrane methodological standards.
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Cochrane Db Syst Rev · Nov 2021
Review Retraction Of PublicationPharmacotherapy for smoking cessation: effects by subgroup defined by genetically informed biomarkers.
This review has been withdrawn because it has been found to be in breach of the Cochrane Commercial Sponsorship policy clause 2: 'Individuals who are currently employed or where employed any time in the last three years by a company that has a real or potential financial interest in the outcome of the review (including but not limited to drug companies or medical device manufacturers); or who hold or have applied for a patent related to the review are prohibited from being Cochrane Review authors. In most cases, current or previous employment would be characterized by the affiliation statement made by the author at the title registration, protocol, or review stage of the review'.
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Cochrane Db Syst Rev · Nov 2021
Review Retraction Of PublicationInterventions for tobacco use prevention in Indigenous youth.
This review has been withdrawn because it does it does not include recent evidence and does not reflect up-to-date Cochrane methodological standards.