Isr Med Assoc J
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Multiple myeloma (MM) accounts for approximately 10% of hematological malignancies. The monoclonal immunoglobulin G kappa (IgG-κ) daratumumab can bind to CD38 on MM cells and be detected in serum immunofixation (IF), causing pitfalls in M-protein quantification. ⋯ The Hydrashift assay can help distinguish daratumumab from endogenous M-spike.
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The coronavirus disease 2019 (COVID-19) pandemic has resulted in more than four million deaths globally. In addition to the lower respiratory system, a wide range of major organ injuries have been reported among patients infected with COVID-19. These injuries include cardiac involvement. ⋯ Different mechanisms are proposed, including direct myocyte injury, interstitial inflammation and fibrosis, cytokine storm, plaque destabilization, and and/or hypoxia [3]. Many countries have worked toward mass vaccination using the Pfizer BioNTech (BNT162b2) COVID-19 vaccine, including Israel. We report a case of high degree atrioventricular block (AVB) following vaccination with the COVID-19 BNT162b2 vaccine.
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Rare incidence cases are part of the routine work of pediatric surgeons. Cecal anomalies in children are an example of such cases. Objectives: To describe the presentation, workup, management and outcome of rare cecal anomalies in children and to analyze the skills needed for their successful treatment. ⋯ A wide knowledge base, careful judgment, and creativity enable pediatric surgeons to successfully treat rare conditions such as rare cecal anomalies. These skills should be part of the education of pediatric surgery trainees.
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Gestational hypertensive (GH) disorders remain a major obstetric problem. ⋯ The incidence of GH and preeclampsia in participants was higher among those exposed to 1-2 cycles than those exposed to 3+ cycles of IUI.
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Hospitalization is an inherently serious event in the oldest-old, as the risk of complications associated with it increases exponentially with age and can lead to death. Despite the size of the problem, few studies have been dedicated to determining mortality predictors among hospitalized older patients, particularly among the oldest-old. Objectives: To examine in-hospital mortality predictors in the oldest-old adults hospitalized in an acute geriatric ward. ⋯ Careful evaluation of mortality predictors might be useful for therapeutic planning and identification of potential inpatients for specific interventions. Awareness of in-hospital mortality predictors might contribute to reducing in-hospital death.