Isr Med Assoc J
The most recent articles from:
Isr Med Assoc J
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Review
Methotrexate-related neurotoxicity in the treatment of childhood acute lymphoblastic leukemia.
The addition of methotrexate to treatment protocols in children with acute lymphoblastic leukemia has been found beneficial in preventing central nervous system relapse. However, MTX itself may be associated with neurologic morbidities, the most significant of which is leukoencephalopathy. ⋯ A summary is presented of the metabolic pathways that may be involved in the development of MTX toxicity. Researchers are still seeking a biochemical marker to aid in the determination of the amount of MTX that may be safely administered.