J Formos Med Assoc
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Quality of life (QOL) is important for evaluating medical care outcomes. In chronic kidney disease (CKD) population, generic instruments, such as WHOQOL-BREF and EQ-5D, are commonly used for comparing various medical conditions for policy-making purposes. However, their psychometric properties have not yet been validated in non-dialysis CKD population. ⋯ Both WHOQOL-BREF (TW) and EQ-5D have relatively good psychometric properties in non-dialysis CKD population. The direct use of original WHOQOL-BREF (TW) domain scores/EQ-5D utility score for parametric analyses is acceptable non-dialysis in CKD population. However, when using the EQ-5D for cost-effective comparison in CKD patients with different stages or characteristics potential bias should be concerned.
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Osteoporosis fracture is a common and most serious complication of osteoporosis. ⋯ MiR-4534 is a new potential diagnostic biomarker for osteoporotic fractures. MiR-4534 can regulate osteoblast differentiation, proliferation, and migration by targeting CFTR.