Natl Med J India
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Salmonella infection causes a wide range of intestinal and extraintestinal manifestations as well as a lifetime carrier state. Untreated patients may develop complications, which can be life-threatening. ⋯ Ventricular bigeminy in enteric fever is a rare phenomenon. We report its occurrence in a patient.
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Observational Study
Slow parasite clearance, absent K13-propeller gene polymorphisms and adequate artesunate levels among patients with malaria: A pilot study from southern India.
Artemisinin-based combination therapy (ACT) is widely used in India and many generic preparations are available. Delayed response has been reported, suggesting inadequate response to artesunate (AS) or genotypic resistance. We designed a prospective observational study to assess the therapeutic response, elaborate pharmacokinetics of AS and identify Plasmodium falciparum kelch 13 (pfk13) propeller gene polymorphisms among hospitalized Indian patients with severe malaria. ⋯ Slow parasite CL was seen with a high parasite burden without genotypic evidence of AS resistance. There is a need to standardize definitions of therapeutic efficacy of AS in cases of severe malaria.
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Knowledge of cognition and its regulation are important meta-cognitive activities, which are crucial for enhancement of learning. Their explicit teaching is meaningful and necessary yet seldom undertaken systematically in medical education programmes. ⋯ Incorporation of meta-cognitive learning practices in medical education offers a basis for enhancing classroom teaching, thereby making it learner-centric. The study helped students in identifying the way they process information and in identifying their preferred methods of assimilating knowledge. Identification of cognitive diversity is a primary pedagogic act for improving competence in learning. Meta-cognitive skills can be harnessed to bring about consonance of the left, right and middle brain cognitive styles to achieve better learning outcomes.