Niger J Clin Pract
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Anti-citrullinated peptides antibodies (ACPA) are specific for rheumatoid arthritis and have been implicated in disease pathogenesis. ACPA examination is a new component of ACR/EULAR 2010 classification criteria for rheumatoid arthritis. ACPA positivity predicts a more erosive disease course with severe joint damage and extra-articular manifestations. ⋯ The study was placed in Slovak Republic. We examined 833 patients with arthritis. There were 43 patients, or 62% of a subgroup of 69 who were ACPA positive whose ACPA examination was not needed-ACR/EULAR criteria was met without ACPA scoring. This number represents 5.1% of the total number examined. There were 15 patients, or 22% of the subgroup and 1.8% of the total whose diagnosis was revised to rheumatoid arthritis due to ACPA positivity-ACR/EULAR criteria were met solely with ACPA scoring. There were 11 patients (16% and 1.3%) whose medication was changed due to ACPA positivity. ACPA examination is useful in 3.1% of all examined patients. When we correlate data on ACPA positive patients, 38% of the patients profit from ACPA examinations. Considering the relatively low price of ACPA testing, this examination should not be excluded.
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Comparative Study
Intrauterine insemination in ovulatory infertile patients.
Although there are many studies in literature comparing intrauterine insemination (IUI) and timed intercourse, there are only a few studies examining the use of clomiphene citrate (CC) in ovulatory infertile patients. The aim of this study was to compare IUI following CC-induced ovulation and timed intercourse following CC-induced ovulation in ovulatory infertile patients. ⋯ In the patients who had OI via CC, the pregnancy rates obtained with IUI were statistically significantly higher than timed intercourse.