Patient Prefer Adher
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Patient Prefer Adher · Jan 2016
Development and validation of a predictive model of failed stepping-down of inhaled corticosteroids in adult asthmatics.
Asthma guidelines suggest stepping-down of inhaled corticosteroids (ICSs) when asthma is stable. ⋯ Our results suggest that comorbidity with rhinitis/rhinosinusitis and phlegm grade are imperative to predict failed stepping-down of ICSs in controlled patients with adult asthma.
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Patient Prefer Adher · Jan 2016
Interleukin-18 and miR-130a in severe sepsis patients with thrombocytopenia.
Thrombocytopenia is one of the most common laboratory abnormalities encountered in patients with severe sepsis. It has been reported that thrombocytopenia is linked to mortality in patients with severe sepsis. However, the mechanism of thrombocytopenia in sepsis is unknown. We hypothesized that inflammatory cytokines and microRNAs (miRNAs) are not only involved in the pathogenesis of sepsis, but also are correlated with thrombocytopenia. ⋯ Our data demonstrate that severe sepsis patients with thrombocytopenia have increased plasma and miRNA expression levels of IL-18 and decreased expression of miR-130a, suggesting that IL-18 and miR-130a might be involved in the pathophysiological process of severe sepsis with thrombocytopenia.
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Patient Prefer Adher · Jan 2016
Impact of overweight and obesity on the musculoskeletal system using lumbosacral angles.
Overweight and obesity have been identified as independent risk factors for musculoskeletal disorders. However, the association between obesity and low back pain remains controversial. Little is known about the effects of overweight and obesity on the angles of the lumbosacral spine. The objective of this study was to evaluate the effects of body mass index (BMI) and waist-hip ratio (WHR) on lumbosacral angles. ⋯ There was an increase in lumbosacral angles in individuals with raised BMI and WHR. This may result in biomechanical changes in the lumbosacral spine, which increase the incidence of low back pain.
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Patient Prefer Adher · Jan 2016
Association of psychological factors, patients' knowledge, and management among patients with erectile dysfunction.
Erectile dysfunction (ED) is one of the most common health problems in men. ED can significantly affect a man's psychological well-being and overall health. ⋯ This study concluded that ED does affect psychological well-being of people. In addition, patient's knowledge about ED and its management is also crucial in ensuring that the patient achieves optimal therapeutic outcomes from ED therapy.
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Patient Prefer Adher · Jan 2016
Illness perceptions and stress: mediators between disease severity and psychological well-being and quality of life among patients with Crohn's disease.
Disease severity, illness perceptions, coping strategies, stress, psychological well-being, and quality of life were reported to have close relationships. According to the Common Sense Model, illness perceptions and coping strategies could mediate the relationship between illness stimuli and illness outcomes such as psychological health and quality of life. Stress was also associated with the individual's disease severity, anxiety, depression, and quality of life. ⋯ Interrelationships between disease stimuli, disease perceptions and management and disease outcomes could be found in patients with Crohn's disease. Illness perceptions and stress mediated an individual's disease severity and anxiety, depression and quality of life, while coping strategy was not an applicable mediator.