Presse Med
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Randomized Controlled Trial Comparative Study Clinical Trial
[Pristinamycin in the treatment of acute communicable pneumopathies in adults].
ALTERNATIVE TO BETA-LACTAMS: Due to the rapid and increasing development of resistance in the two main bacteria, S. pneumoniae and H. influenzae, it is important to determine whether pristinamycin, with known efficacy against these germs, could be a useful alternative to beta-lactams for the treatment of adult acute community-acquired pneumonia.
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Review Randomized Controlled Trial Clinical Trial
[Type 2 diabetes: new therapeutic perspectives].
UKPDS: The results of the United Kingdom Prospective Diabetes Study (UKPDS) were reported in 1998. This multi-center, prospective, randomized, intervention trial of 5102 newly-diagnosed patients with type 2 diabetes mellitus was aimed at determining whether improved blood glucose control can prevent complications and reduce associated morbidity and mortality.
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Randomized Controlled Trial Multicenter Study Clinical Trial
[Functional manifestations of osteoarthritis: key points to the clinical efficacy of diacerhein].
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Randomized Controlled Trial Comparative Study Clinical Trial
[Catheter infection in intensive care: influence of systematic replacement of central venous catheters on a guide wire every 4 days].
Determine whether systematic replacement of central venous catheters on a guide wire every 4 days leads to a lower rate of catheter infection. ⋯ We do not recommend systematically replacing catheters on a guide wire for the prevention of catheter infection. This procedure may however be indicated in case of suspected catheter infection as no mechanical of infectious complications occurred.
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Randomized Controlled Trial Multicenter Study Clinical Trial
[Analgesic effect and clinical tolerability of the combination of paracetamol 500 mg and caffeine 50 mg versus paracetamol 400 mg and dextropropoxyphene 30 mg in back pain].
A double-blind randomized multicentric study was performed to test the hypothesis that the analgesic effect of paracetamol-cafeine is equivalent to that of paracetamol-dextropropoxyphen in patients suffering from pain due to osteoarthritis of the spine. ⋯ The potentializing action of cafeine on paracetamol-induced pain relief enables a degree of pain relief equivalent to that of a combination using an analgesic with a peripheral action, paracetamol, and another with a central action, dextropoxyphen. The fact that the paracetamol-cafeine combination does not have a central action avoids secondary effects induced by central analgesics (drowsiness, constipation) in patients with osteoarthritis back pain.