Presse Med
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Review Randomized Controlled Trial Clinical Trial
[Type 2 diabetes: new therapeutic perspectives].
UKPDS: The results of the United Kingdom Prospective Diabetes Study (UKPDS) were reported in 1998. This multi-center, prospective, randomized, intervention trial of 5102 newly-diagnosed patients with type 2 diabetes mellitus was aimed at determining whether improved blood glucose control can prevent complications and reduce associated morbidity and mortality.
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Randomized Controlled Trial Multicenter Study Clinical Trial
[Functional manifestations of osteoarthritis: key points to the clinical efficacy of diacerhein].
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Randomized Controlled Trial Comparative Study Clinical Trial
[Catheter infection in intensive care: influence of systematic replacement of central venous catheters on a guide wire every 4 days].
Determine whether systematic replacement of central venous catheters on a guide wire every 4 days leads to a lower rate of catheter infection. ⋯ We do not recommend systematically replacing catheters on a guide wire for the prevention of catheter infection. This procedure may however be indicated in case of suspected catheter infection as no mechanical of infectious complications occurred.
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Randomized Controlled Trial Multicenter Study Clinical Trial
[Analgesic effect and clinical tolerability of the combination of paracetamol 500 mg and caffeine 50 mg versus paracetamol 400 mg and dextropropoxyphene 30 mg in back pain].
A double-blind randomized multicentric study was performed to test the hypothesis that the analgesic effect of paracetamol-cafeine is equivalent to that of paracetamol-dextropropoxyphen in patients suffering from pain due to osteoarthritis of the spine. ⋯ The potentializing action of cafeine on paracetamol-induced pain relief enables a degree of pain relief equivalent to that of a combination using an analgesic with a peripheral action, paracetamol, and another with a central action, dextropoxyphen. The fact that the paracetamol-cafeine combination does not have a central action avoids secondary effects induced by central analgesics (drowsiness, constipation) in patients with osteoarthritis back pain.
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
[Efficacy of single dose of ciprofloxacin and pefloxacin in the treatment of female acute cystitis].
A multicentric double-blind double-placebo randomized trial was conducted to compare the effectiveness and safety of ciprofloxacin versus pefloxacin given in a single oral dose in female out-patients with acute cystitis. ⋯ These findings demonstrate that ciprofloxacin and pefloxacin are equally effective and equally well tolerated as single-dose oral curative therapy for acute cystitis in women.