Saudi Med J
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To evaluate the prevalence of vitamin D deficiency among a group of Saudi children with type 1 diabetes mellitus (T1DM) in Armed Forces Hospital and Riyadh Care Hospital in Riyadh, Kingdom of Saudi Arabia. Methods: The study was carried out in Riyadh Armed Forces Hospital and Riyadh Care Hospital in Riyadh, Kingdom of Saudi Arabia, from January to June 2017. This study included a total of 100 Saudi (50 males and 50 females) participants with T1DM, aged 2-12 years old. ⋯ Serum 25(OH) vitamin D was significantly inversely associated with body mass index as well as HbA1c. Conclusion: There is a concern that growing children with low vitamin D may be at higher risk for T1DM. It is necessary to further examine the mechanisms underlying vitamin D deficiency in T1DM children.
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To evaluate the effects of platelet-rich plasma (PRP) on promoting neural repair after facial nerve compression in rats and the mechanism by which this occurs. Methods: Adult Wistar rats (n=100) were divided into 3 groups: healthy controls, surgery-only, and surgery+PRP groups. The rats underwent nerve crush injury to establish a facial palsy model. The blood from the rats was used to prepare the PRP for application to the injury site. ⋯ Hematoxylin and eosin staining, toluidine blue staining, and electron microscopy showed significant recovery of Schwann cells and axons in the PRP group. Polymerase chain reaction results showed that PRP releases growth factors, which include nerve growth factor and brain-derived neurotrophic factor. Immunohistochemistry also demonstrated higher levels of S-100 protein expression in the PRP group compared to the other groups. Conclusions: Platelet-rich plasma releases nutrient factors in the brainstem, and the use of PRP can promote injury recovery.