Scot Med J
The most recent articles from:
Scot Med J
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Retracted Publication
Metformin prevents brain injury after cardiopulmonary resuscitation by inhibiting the endoplasmic reticulum stress response and activating AMPK-mediated autophagy.
The neurological damage caused by cardiac arrest (CA) can seriously affect quality of life. We investigated the effect of metformin pretreatment on brain injury and survival in a rat CA/cardiopulmonary resuscitation (CPR) model. ⋯ In a CA/CPR rat model, 14-day pretreatment with metformin has a neuroprotective effect. This effect is closely related to the activation of AMPK-induced autophagy and inhibition of the ER stress response. Long-term use of metformin can reduce brain damage following CA/CPR.
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At the request of the Journal Editor and the Publisher, the following article has been retracted. Sajid M. S. ⋯ M. Bioethics and Medical Education. Journal of Pakistan Medical Association 2003; 53 (6): 210-214.