Singap Med J
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Randomized Controlled Trial Comparative Study Clinical Trial
Nausea and vomiting after termination of pregnancy as day surgery cases: comparison of 3 different doses of droperidol and metoclopramide as anti-emetic prophylaxis.
Frequency of nausea and vomiting following day case termination of pregnancy was found to be rather high (42%) without anti-emetic prophylaxis. Droperidol in doses of 2.5 mg, 1.25 mg and 0.25 mg were found to be equally effective as prophylactic anti-emetic, but not metoclopramide 10 mg. This study confirms that low dose droperidol 0.25 mg is effective as a prophylactic anti-emetic, without any delay in immediate recovery and hence suitable for day surgery cases.
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Randomized Controlled Trial Clinical Trial
Preoxygenation in parturients: a comparison of 4, 6 and 8 vital capacity breaths to 5 minutes of tidal volume breathing.
We compared the difference in denitrogenation (by intermittent measurement of arterial tension, PaO2) in 45 parturients at term when preoxygenated with 4, 6 or 8 rapid vital capacity breaths and 5 minutes of tidal volume breathing. Oxygen, at 8 litres min-1, was delivered through a facemask via a circle absorber with a 2 litre reservoir bag. Higher PaO2 was produced with 5 minutes of tidal volume breathing. This differed significantly from the PaO2 produced by 4, 6 or 8 rapid vital capacity breaths (p less than 0.01).
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Randomized Controlled Trial Clinical Trial
Comparative study on the effect of Diane and Microgynon 50 contraceptive on the haemostatic mechanisms in Chinese subjects.
A longitudinal controlled study on the effect of Diane and Microgynon 50 (Micro 50) contraceptive pills on the haemostatic mechanisms in 59 Chinese subjects was carried out. Diane, containing the potent anti-androgen progestagen, cyproterone acetate was used as a contraceptive and in subjects requiring anti-androgenic treatment and fertility control. Enhanced fibrinolytic activity with raised plasminogen and alpha 1-antitrypsin (a1-AT) was observed in all subjects after pill treatment. ⋯ More changes in haemostasis were seen after treatment with Diane containing 35 ug and 50 ug ethinyl estradiol (EE) formulation than during Micro 50 treatment. The results from this study show that Diane even with 35 ug EE formulation caused coagulation changes which were more pronounced than the 50 ug EE Microgynon. The finding is at variance with others that ascribe haemostatic changes observed to increased oestrogen content in a given pill formulation and so merits confirmation in a larger study.
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Randomized Controlled Trial Clinical Trial
Vomiting after anaesthesia for termination of pregnancy in Chinese.