Srp Ark Celok Lek
-
During a nine-month period we have treated 46 patients with status epilepticus with intravenous application of diazepam or midazolam. The initial doze od diazepam was 10 mg (rate: 2-5 mg/min) and of midazolam 15 mg (rate: 5 mg/min). Diazepam was effective in 26 and ineffective in 15 patients. ⋯ All patients with apnea or respiratory depression received higher doses of both drugs at the higher rates than the others. We conclude that the efficacy of the therapy is moderate while the frequency of serious complications is high. In status epilepticus, where the life of patient is in danger, drugs with such activity are of limited value.
-
A large number of studies have shown that beta-blockers are useful in the treatment of angina pectoris. Favorable effects of beta blockers are decreased heart rate, contractility and wall tension, the three main causes of myocardial oxygen consumption. ⋯ Beta-blockers are standard therapy for patients with stable angina pectoris, silent myocardial ischemia and unstable angina pectoris. In the treatment of all these forms of myocardial ischemia beta-blockers could be used in conjuction with nitrates and calcium antagonists.