Terapevt Arkh
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To evaluate the efficiency of related and unrelated allogeneic bone marrow transplantation (alloBMT) versus immunosuppressive therapy (IST) in patients with aplastic anemia (AA) having no HLA-compatible bone marrow donor. ⋯ Related allo-BMT is the method of choice if there is a HLA-compatible sibling. If there are contraindications to it or no related donor, IST with ATG + CsA is indicated. Ineffective IST is an indication for unrelated allo-BMT that may be recommended as life-saving therapy for young patients under 40 years of age.
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To study aortic stiffness in patients with chronic obstructive pulmonary disease (COPD) concurrent with coronary heart disease (CHD). ⋯ In COPD concurrent with CHD, central arterial stiffness is drastically increased as compared to that in healthy individuals and patients with COPD alone. There are no differences in the values of coronary perfusion in isolated COPD and its association with CHD, suggesting that COPD is of its own value in the formation of a cardiovascular risk. The correlation between the major parameters of aortic stiffness and the level of hypoxemia, on the one hand, and decreased lung ventilation function, on the other, testify their great contribution to the increase in the stiffness of elastic-type vessel walls in CHD-associated COPD.
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To investigate hemostasis disorders caused by massive blood transfusions of artificial plasma replacing solutions (PRS). ⋯ Moderate hemodilution with PRS in vivo causes hypercoagulation which persisted longer than volemic effect of PRS.
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Clinical Trial
[Phenomenon of synergism of immunodepressive drugs (addition of campath to the protocol of immunodepression)].
To determine kempas ability to potentiate the action of simultaneously used daklizumab. ⋯ Kempas potentiates an immunodepressive action of daklizumab.