Terapevt Arkh
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To study effects of a selective beta1-adrenoblocker (B1AB) bisoprolol fumarate (conkor, Nikomed, Germany) on severity of pulmonary hypertension (PH), bronchial obstruction and bioelectric activity of the myocardium in patients with chronic obstructive pulmonary disease (COPD) associated with ischemic heart disease (IHD). ⋯ Bisoprolol is well tolerated, effective and safe in COPD patients with IHD.
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To quantitatively determine minimal residual disease (MRD) by real-time polymerase chain reaction (PCR) in patients with a chronic phase (CP) of chronic myeloid leukemia (CML). ⋯ Quantitative monitoring by real-time PCR gives additional information on the dynamics of MRD in CML patients treated with glivec and permits improvement of study protocols for patients with CML at complete clinicohematological and cytogenetic remission.
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To determine the death risk factors in patients with chronic obstructive pulmonary disease (COPD) in the course of a follow-up and to study feasibility of BODE index use for prognosis in COPD patients. ⋯ BODE index can be used as a simple integrative index of death risk in COPD.