Terapevt Arkh
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To characterize actions of beta-blockers and Ca antagonists (verapamil and diltiazem) on the rate, structure and parameters of ventricular rhythm variability in constant cardiac fibrillation (CCF) and to evaluate validity of monotherapy with these drugs. ⋯ Monotherapy with AB-blocking drugs was possible only in patients with moderate tachycardia, no waves of fibrillation of large and middle periods (0.15 s and higher) and should be conducted under Rrmin control. In the other cases, the above drugs are either low effective or promote non-optimal rhythm structure. Therefore, combined therapy with AB-blocking drugs and cardiac glycosides is indicated for CCF patients.
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To study correlation between polymorphism of the genes of vitamin D3 (VDR3), collagen of type 1 alpha-1 (COL1A1) and markers of bone tissue metabolism in chronic obstructive pulmonary disease ⋯ Testing of VDR3 and COL1A1 genes gives grounds for detection of predisposition to development of pulmonogenic osteopenic syndrome.
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Randomized Controlled Trial Comparative Study Clinical Trial
[Results of an open prospective controlled randomized comparative trial of flurbiprofen and paracetamol efficacy and tolerance in patients with throat pain].
To compare efficacy and safety of strepfen (flurbiprofen) to those of oral paracetamol in acute infections of the upper respiratory tracts for relief of throat pain (TP). ⋯ Strepfen can be recommended for relief of throat pains and pharyngeal paresthesia in patients with acute and chronic pharyngeal pathology.
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To evaluate trends in mortality of ischemic heart disease (IHD) and stroke in Kaunas population aged 25-64 years in 1983 to 2002. ⋯ In 1983-2002, both IHD and stroke mortality rates among both Kaunas men and women aged 25-64 years decreased significantly.