Turk J Med Sci
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Meningiomas are the most common primary brain tumors of the central nervous system. Immunotherapy is a promising treatment method applied in many types of cancer. There is no standard and effective medical treatment to reduce recurrence and mortality in cases of incomplete resection of meningiomas and in high-grade cases. In order to investigate medical treatments in addition to surgery and radiotherapy, in this study, the status of immune checkpoint molecules (PD-L1/PD-1), which are the target of immunotherapy, in meningiomas was investigated. ⋯ With these data, it was observed that the expression of immune checkpoint molecules PD-L1 and PD-1 increased especially in high-grade meningiomas. It may be the subject of research that these molecules may be targets of immunotherapy in the treatment of meningiomas.
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The Memorial Sloan Kettering Cancer Center (MSKCC) nomogram was developed to predict survivorship in gastric cancer patients undergoing R0 resection. This study aimed to evaluate the predictive power of this nomogram in the Turkish patient population. ⋯ The 5- and 9-year survival rates estimated using the MSKCC tool were correlated with the 5- and 9-year survival rates in the real-life data. Hence, the use of the MSKCC prognostic tool in clinical practice should be expanded.
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This study aimed to scrutinize nationwide utilization trends of shoulder arthroplasty for proximal humerus fractures (PHFs) using a comprehensive national surgical database. ⋯ Level III, retrospective cohort study.
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Functional asymmetry in the upper extremities may occur in infants with neuromotor problems due to neurodevelopmental or musculoskeletal disorders. The aim of this study was to investigate the validity and reliability of the Turkish version of the Infant Motor Activity Log (IMAL-T), which assesses the frequency (how often) and quality (how well) of the affected arm usage during activities in infants with functional asymmetry in the upper extremities. ⋯ The IMAL-T is a reliable and valid parent-reported outcome measure that indicates the frequency and quality of the affected arm use during age-appropriate real-life activity in infants aged 6-24 months with upper extremity functional asymmetry due to neuromotor problems. The IMAL-T can be used in early intervention to assess upper extremity functional asymmetry in Turkish infants.
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Menopause is often accompanied by neurological symptoms, including cognitive difficulties, especially with memory and attention. The purpose of the present study was to examine the relationship between the timing of menopause and the cognitive performance of menopausal patients who applied to our neurology clinic with complaints of forgetfulness. ⋯ The relationship between the cognitive performance of menopausal women and the timing of menopause was examined herein. The ACE-R, attention and orientation, visual, verbal fluency, and memory scores were significantly higher in women ≥50 years of age who entered menopause compared to those <40 years of age and those between 40 and 50 years of age. This study provides evidence that advancing age at menopause is associated with better cognitive performance. This relationship is most evident in the areas of the attention, verbal fluency, memory, and visuospatial domains.