Scandinavian journal of gastroenterology
-
Scand. J. Gastroenterol. · Jan 2016
Randomized Controlled Trial Multicenter Study Comparative StudyInflammatory response to surgical trauma in patients with minilaparotomy cholecystectomy versus laparoscopic cholecystectomy: a randomised multicentre study.
The aim of the study was to evaluate the inflammatory response to surgical trauma in minilaparotomy cholecystectomy (MC) compared to laparoscopic cholecystectomy (LC). Assessment of inflammatory response to surgical trauma in MC has not been addressed properly. Therefore, we investigated five interleukins (IL) and C-reactive protein (CRP) in MC versus LC group in a prospective randomised trial. ⋯ Our results suggest that the inflammatory response in MC versus LC groups was similar based on the IL-8, IL-10, and IL-1β values. A new finding with possible clinical relevance in the present work is higher relative elevation of the IL-1ra and IL-6 mean values post-operatively in the MC group.
-
Scand. J. Gastroenterol. · Jan 2016
Comparative Study Controlled Clinical TrialComparison of three commercial fecal calprotectin ELISA test kits used in patients with Inflammatory Bowel Disease.
Fecal calprotectin is a noninvasive marker of intestinal inflammation used to distinguish between functional and organic bowel diseases and to evaluate disease activity among patients with Inflammatory Bowel Disease (IBD). The goal of this study was to compare three different ELISA tests measuring calprotectin in their accuracy to detect IBD and to distinguish between IBD patients with active or inactive disease. ⋯ The CALPRO ELISA test performed best in measuring calprotectin in feces.
-
Scand. J. Gastroenterol. · Aug 2015
A stepwise approach for peroral endoscopic myotomy for treating achalasia: from animal models to patients.
Peroral endoscopic myotomy (POEM) was initially developed for the treatment of achalasia. This study aimed to investigate the feasibility and safety of a stepwise approach for POEM in the management of achalasia. ⋯ The ex-vivo porcine esophagus-stomach can be used as a simple and cheap training model that mimics the POEM procedure. POEM is a safe and effective therapy for achalasia patients.