Masui. The Japanese journal of anesthesiology
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Pregabalin has been available in Japan since June 2010 for neuropathic pain. The adverse effects of pregabalin might be serious, and one must start at minimal doses and increase gradually to effective doses with enough explanation to patients. Pregabalin is a derivative of y-aminobutyric acid (GABA), but it has no effects on GABA receptors. ⋯ The effects of pregabalin is to bind alpha2delta-1 subunit and normalize the numbers of VGCCs at neuron surface and decreases neurotransmission, especially by excitatory amino acid. The descending facilitating serotonergic system from rostral ventromedial medulla may have effects on the occurrence and maintenance for the chronic pain. New drugs with less adverse effects may be developed.
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Randomized Controlled Trial Meta Analysis Comparative Study
[Channeled videolaryngoscope: A meta-analysis of randomized controlled trials].
The aim of this meta-analysis was to assess the efficacy of the channeled videolaryngoscopes in routine tracheal intubation. ⋯ Compared to the Macintosh laryngoscopy, channeled videolaryngoscopy offers advantages for novice laryngoscopists, while these benefits are not seen with experts' hands in normal airways. Even with skillful hands, channeled videolaryngoscopy improves the successful first-attempt intubation in difficult intubations.
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The effects of the addition of remifentanil or nitrous oxide (N2O) on hemodynamics and bispectral index score (BIS) during surgery were exam-ined. ⋯ The effects of remifentanil on hemodynamics and bispectral index score in patients during surgery under sevoflurane/epidural anesthesia were completely different from those of N2O.
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A 77-year-old man was scheduled to undergo the resection of hepatoma. After the induction of general anesthesia, a central venous (CV) catheter was inserted from the right internal jugular vein under the echographic observation. Then, we noticed that the size of the vein was smaller than usual, which caused a little difficulty in the insertion. ⋯ Re-evaluation of preoperative CT revealed the persistent left superior vena cava (PLSVC) with absent right superior vena cava. Post-operative examination with echography of the neck showed that the left internal jugular vein was much greater than the right. When noticing a small right internal jugular vein in pre-procedure echography, existence of PLSVC should be considered, and meticulous CV catheterization is necessary for safety.
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Comparative Study
[Effect of continuous interscalene block with ropivacaine at a low concentration on postoperative pain relief after arthroscopic rotator cuff reconstruction].
The analgesic effect of continuous interscalene block with ropivacaine at a low concentration was compared with that of single-shot interscalene block after arthroscopic rotator cuff reconstruction (ARCR). ⋯ Postoperative continuous interscalene block with 0.1% ropivacaine provided sufficient analgesia without complete motor block.