Systematic reviews
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Whilst nutrition is vital to survival in health, the precise role of nutrition during critical illness is controversial. More specifically, the exact amount of energy that is required during critical illness to optimally influence clinical outcomes remains unknown. The aim of this systematic literature review and meta-analysis is to evaluate the clinical effects of optimising nutrition to critically ill adult patients, such that the entire predicted amount of energy that the patient requires is delivered, on mortality and other important outcomes. ⋯ PROSPERO CRD42015027512.
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Fluid administration to critically ill patients remains the subject of considerable controversy. While intravenous fluid given for resuscitation may be life-saving, a positive fluid balance over time is associated with worse outcomes in critical illness. The aim of this systematic review is to summarise the existing evidence regarding the relationship between fluid administration or balance and clinically important patient outcomes in critical illness. ⋯ PROSPERO CRD42013005608. ( http://www.crd.york.ac.uk/PROSPERO/ ).
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Meta Analysis
Clonidine for sedation in the critically ill: a systematic review and meta-analysis (protocol).
Management and choice of sedation is important during critical illness in order to reduce patient suffering and to facilitate the delivery of care. Unfortunately, medications traditionally used for sedation in the intensive care unit (ICU) such as benzodiazepines and propofol are associated with significant unwanted effects. Clonidine is an alpha-2 selective adrenergic agonist that may have a role in optimizing current sedation practices in the pediatric and adult critically ill populations by potentially minimizing exposure to other sedative agents. ⋯ PROSPERO CRD42015019365.
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Meta Analysis
NatHER: protocol for systematic evaluation of trends in survival among patients with HER2-positive advanced breast cancer.
Human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer (MBC) is an aggressive form of breast cancer and is historically associated with poor outcomes compared with HER2-negative MBC. Since 1998, four drugs have been globally approved for the targeted treatment of HER2-positive MBC. Additional advances in patient care-such as improved breast cancer screening, HER2 testing, and supportive care-have also occurred. The objective of this systematic review and meta-analysis is to determine whether there has been a cumulative change in survival over time in patients with HER2-positive advanced breast cancer based on results from interventional clinical trials (ICTs) and observational studies and to compare outcomes across these types of studies. ⋯ PROSPERO CRD42014014345.
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Biased processing of body-related information may be linked to the development and maintenance of eating disorders (ED). The objective of this systematic review will be to examine the occurrence and the extent of cognitive biases in response to visual body-related stimuli in individuals with ED and individuals with an increased risk to develop ED. ⋯ PROSPERO CRD42015019165.