The Lancet. Respiratory medicine
-
There are few prospective data about the incidence and mortality associated with pulmonary tuberculosis in intensive care units (ICUs), and none on the accuracy and clinical effect of the Xpert-MTB/RIF assay in this setting. We aimed to measure the frequency of culture-positive tuberculosis in ICUs in Cape Town, South Africa and to assess the performance and effect on patient outcomes of Xpert MTB/RIF versus smear microscopy for diagnosis of tuberculosis. ⋯ European and Developing Countries Clinical Trials Partnership, South African Medical Research Council, and the Discovery Foundation.
-
Randomized Controlled Trial Multicenter Study
Permissive hypercapnia in extremely low birthweight infants (PHELBI): a randomised controlled multicentre trial.
Tolerating higher partial pressure of carbon dioxide (pCO2) in mechanically ventilated, extremely low birthweight infants might reduce ventilator-induced lung injury and bronchopulmonary dysplasia. We aimed to test the hypothesis that higher target ranges for pCO2 decrease the rate of bronchopulmonary dysplasia or death. ⋯ Deutsche Forschungsgemeinschaft.