World journal of gastroenterology : WJG
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World J. Gastroenterol. · Dec 2014
2,4,6-trinitrobenzene sulfonic acid-induced chronic colitis with fibrosis and modulation of TGF-β1 signaling.
To investigate whether targeting proteasome might reverse intestinal fibrosis in rats. ⋯ Rats with TNBS-induced chronic colitis exhibited colon fibrosis associated with higher TGF-β signaling. Proteasome inhibition by bortezomib had no effect on fibrosis in our experimental conditions.
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World J. Gastroenterol. · Dec 2014
Comparative StudyCost-effectiveness analysis of colon cancer treatments from MOSIAC and No. 16968 trials.
To compare XELOX and FOLFOX4 as colon cancer adjuvant chemotherapy based on MOSAIC and No. 16968 trails from Chinese cost-effectiveness perspective. ⋯ In term of cost-comparison, XELOX is expected to dominate FOLFOX4 regimes; Therefore, XELOX provides a more cost-effective adjuvant chemotherapy for colon cancer patients in China.
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World J. Gastroenterol. · Dec 2014
Lean-non-alcoholic fatty liver disease increases risk for metabolic disorders in a normal weight Chinese population.
To study the prevalence and clinical biochemical, blood cell and metabolic features of lean-non-alcoholic fatty liver disease (lean-NAFLD) and its association with other diseases. ⋯ Lean-NAFLD has unique results in demographic, biochemical and blood examinations, and adds significant risk for diabetes, hypertension and MetS in lean individuals.
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World J. Gastroenterol. · Dec 2014
Effect of bilateral supraclavicular postoperative radiotherapy in middle and lower thoracic esophageal carcinoma.
To evaluate whether postoperative radiotherapy is an alternative to neck lymph node surgery and if it provides a survival benefit for those receiving two-field, chest and abdomen, lymphadenectomy. ⋯ For patients with middle and lower thoracic esophageal carcinoma combined with lymph node metastasis within the recurrent laryngeal nerve, cervical radiotherapy can be a substitute for surgery and provide benefit.
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World J. Gastroenterol. · Dec 2014
Analysis of risk factors for postoperative pancreatic fistula following pancreaticoduodenectomy.
To explore the morbidity and risk factors of postoperative pancreatic fistula (POPF) following pancreaticoduodenectomy. ⋯ A pancreatic duct diameter ≤ 3 mm is an independent risk factor for POPF. External stent drainage of pancreatic secretion may reduce CR-POPF mortality and POPF severity.