Postgraduate medicine
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Postgraduate medicine · Jun 2022
Randomized Controlled TrialAnalgesic efficacy of naproxen sodium versus hydrocodone/acetaminophen in acute postsurgical dental pain: a randomized, double-blind, placebo-controlled trial.
Opioid/acetaminophen combinations may be overly prescribed in many post-surgical situations where a non-steroidal anti-inflammatory drug with equal or greater efficacy, fewer central nervous system side effects, and no risk for opioid abuse could be substituted. We compared a single, non-prescription dose of naproxen sodium 440 mg (NapS) against hydrocodone plus acetaminophen 10/650 mg (HYD+APAP) in post-impaction surgery pain. ⋯ In moderate-to-severe postsurgical dental pain, a single dose of NapS was at least as effective as HYD+APAP in the early hours, significantly more effective at reducing pain intensity and providing greater pain relief over 12 hours, and was better tolerated. When not contraindicated, NapS should be considered a preferred alternative to opioid combinations for acute pain. (ClinicalTrials.gov, Identifier: NCT04307940; https://clinicaltrials.gov/ct2/show/NCT04307940).
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Postgraduate medicine · Jun 2022
The deadliest lung lobe in COVID-19: a retrospective cohort study of elderly patients hospitalized for COVID-19.
The relationship between which lung lobe is affected on the chest X-ray (CXR) performed at the Emergency Department (ED) and mortality from COVID-19 has not been studied. With this in mind, the present study aimed to discern which lung lobe was the one with the highest associated mortality rate in the elderly population. ⋯ Right middle lobe involvement was an independent predictor of in-hospital mortality.
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Postgraduate medicine · Jun 2022
Low free triiodothyronine levels are associated with frail phenotype in hospitalized inpatients with cirrhosis.
Frailty is a prevalent complication predicting morbidity and mortality in cirrhosis. However, the association between thyroid hormone levels and frailty in cirrhotics remains elusive. Therefore, we aimed to evaluate the relationship between thyroid hormone and frail phenotype in euthyroid patients with cirrhosis. ⋯ In our current study, FT3 < 3.03 pmol/L were significantly associated with increased risk for frailty. Measuring FT3, a readily available biomarker, may be useful for identifying frail phenotype in euthyroid patients with cirrhosis.
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Postgraduate medicine · Jun 2022
Evaluation of stillbirths and infant mortality before and during the COVID-19 pandemic: a retrospective study.
The maternal-child health services remain an important indicator to look at how different countries have handled the pandemic. This study aims to investigate the effect of the COVID-19 pandemic on maternal and child healthcare use and evaluate data on stillbirths and infant mortality. ⋯ In our study, it was determined that the variables of stillbirth and infant mortality during the COVID-19 pandemic period, and maternal and child health services in primary care and hospitals continued to provide services in a similar way to the pre-pandemic period. Compared to pre-pandemic periods during the COVID-19 pandemic, it was found that while the number of stillbirths was similar, there was a significant decrease in infant mortality.
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Postgraduate medicine · Jun 2022
Effect of inadequate care on diabetes complications and healthcare resource utilization during management of type 2 diabetes in the United States.
To estimate the effects of inadequate type 2 diabetes mellitus (T2D) care on health outcomes, utilizing a model that incorporates patient, physician, and health-system factors. ⋯ Inadequate T2D care is an extensive issue that may have substantial economic burden and may lead to increased diabetes-related complications. Those who did not receive medications or laboratory tests that were consistent with ADA guidelines had significantly increased emergency healthcare utilization in the following year. These findings highlight the importance of careful monitoring of T2D.