Archives of surgery (Chicago, Ill. : 1960)
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Randomized Controlled Trial Multicenter Study Comparative Study
Preoperative very low-calorie diet and operative outcome after laparoscopic gastric bypass: a randomized multicenter study.
A 14-day very low-calorie diet (VLCD) regimen before a laparoscopic gastric bypass procedure will improve perioperative and postoperative outcomes. ⋯ Although weight reduction with a 14-day VLCD regimen before laparoscopic gastric bypass performed in high-volume centers seems to reduce the perceived difficulty of the procedure, only minor effects on operating time, intraoperative complications, and short-term weight loss could be expected. However, the finding of reduced postoperative complication rates suggests that such a regimen should be recommended before bariatric surgery.
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Randomized Controlled Trial Comparative Study
Transfusion criteria for fresh frozen plasma in liver resection: a 3 + 3 cohort expansion study.
To establish transfusion criteria for use of fresh frozen plasma (FFP) in liver resection. ⋯ In liver resection, FFP transfusion is not necessary in patients with serum albumin levels higher than 2.4 g/dL on postoperative day 2.
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Randomized Controlled Trial
Perioperative hyperoxygenation and wound site infection following surgery for acute appendicitis: a randomized, prospective, controlled trial.
To assess the influence of hyperoxygenation on surgical site infection by using the most homogeneous study population. ⋯ The use of supplemental oxygen is advantageous in operations for acute appendicitis by reducing surgical site infection rate and hospital stay.
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Randomized Controlled Trial Comparative Study
Evaluating an evidence-based bundle for preventing surgical site infection: a randomized trial.
To determine if an evidence-based practice bundle would result in a significantly lower rate of surgical site infections (SSIs) when compared with standard practice. ⋯ An evidence-based intervention bundle did not reduce SSIs. The bundling of interventions, even when the constituent interventions have been individually tested, does not have a predictable effect on outcome. Formal testing of bundled approaches should occur prior to implementation.
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Randomized Controlled Trial Multicenter Study Comparative Study
Casopitant and ondansetron for postoperative nausea and vomiting prevention in women at high risk for emesis: a phase 3 study.
Postoperative nausea and vomiting (PONV) are associated with a variety of complications. Neurokinin subtype 1 receptor antagonists have antiemetic activity in the postoperative setting, and the neurokinin subtype 1 receptor antagonist casopitant mesylate (GW679769) was well tolerated and effective at reducing the incidence of PONV in phase 1 and phase 2 trials. ⋯ The results of this pivotal phase 3 study demonstrate that the combination of casopitant and ondansetron was superior to ondansetron only in patients at high risk for PONV. Trial Registration clinicaltrials.gov Identifier: NCT00326248.