Zhonghua wei zhong bing ji jiu yi xue
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Oct 2015
Observational Study[The influence of continuous venovenous hemofiltration on parameter measurement by the transpulmonary thermodilution technique].
To evaluate the influence of continuous venovenous hemofiltration (CVVH) on measurement of transpulmonary thermodilution parameters. ⋯ CVVH had no significant effect on the transpulmonary thermodilution measurement of CI, GEDVI, ITBVI and EVLWI. Thirty minutes after the start of CVVH, CI, GEDVI was decreased significantly, but had no effect on EVLWI.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Oct 2015
[A study of using dexmedetomidine in ventilator bundle treatment in an ICU].
To compare the sedative effect and safety of dexmedetomidine and midazolam in the intensive care unit (ICU) patients undergoing ventilator bundle treatment. ⋯ The sedative effects of dexmedetomidine in the ICU patients treated with ventilator bundle treatment are satisfactory, and it can shorten the duration of mechanical ventilation, extubation time and length of ICU stay, reduce the incidence of delirium. However, monitoring should be strengthened in order to prevented and control the adverse effects such as severe hypotension and severe bradycardia.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Oct 2015
[Role and mechanism of the NOD-like receptor 3 inflammasome in ventilator-induced lung injury in rats].
To investigate the role and its mechanism of the NOD-like receptor 3 (NLRP3) inflammasome in alveolar macrophages in ventilator-induced lung injury (VILI) in rats. ⋯ NLRP3 inflammasome in alveolar macrophages may be involved in the mechanism of occurrence of VILI.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Oct 2015
[Reproduction of a model of "two-hit" sepsis model with complication of pneumonia in rat].
To reproduce a clinically relevant "two-hit" model of sepsis complicated by pneumonia and to explore the correlation between "two-hit" and immune state. ⋯ The mortality of this "two-hit" model with complication of pneumonia 4 days after CLP was significantly higher than that of single sepsis model. The ability of bacteria clearance was decreased, and immunocyte apoptosis was exacerbated. These findings may be with the result of the occurrence of immunoparalysis in the mid stage of sepsis. The "two-hit" model reproduced on 7 days after CLP might suggest reconstruction of host immune function, and maybe associated with the recovery of immune response.