Acta neurochirurgica. Supplement
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Acta Neurochir. Suppl. · Jan 2011
Comparative StudyComparison of nimodipine delivery routes in cerebral vasospasm after subarachnoid hemorrhage: an experimental study in rabbits.
nimodipine is the most widely preferred and administered calcium channel blocker in cerebral vasospasm prevention and treatment. There is no experimental or clinical study investigating the comparative effects of routine treatment modalities. ⋯ this is the first study to show the most effective drug delivery route in CVS after SAH. Nimodipine treatment in cerebral vasospasm is useful. This study showed that selective IA nimodipine treatment and IT nimodipine treatment must be preferred to IV and oral treatments of chronic vasospasm following SAH.
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Acta Neurochir. Suppl. · Jan 2011
Recurrent vasospasm after endovascular treatment in subarachnoid hemorrhage.
the frequency and predictors of recurrent symptomatic and angiographic vasospasm after angioplasty or intra-arterial chemical vasodilatation (IACV) in patients with subarachnoid hemorrhage (SAH) are not well characterized. ⋯ recurrent angiographic or symptomatic vasospasm is not uncommon after angioplasty + IACV, but appears to occur significantly less than after IACV alone, without any increase in procedural complications.
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Acta Neurochir. Suppl. · Jan 2011
Case ReportsA numerical approach to patient-specific cerebral vasospasm research.
cerebral vasospasm (CVS) is a devastating sequela of subarachnoid hemorrhage (SAH). Among the many factors that are associated with the pathogenesis of CVS, the cerebral blood flow (CBF) and underlying haemodynamics play an important role. In this paper we present an integrated clinical-engineering approach to CVS research. ⋯ a numerical approach to patient-specific CVS analysis has been established, and some initial results are achieved via application to an actual spasm case. The undergoing and future work include applying the approach to more CVS cases and incorporating computational models of different scales into the current framework for CVS and SAH research.
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Acta Neurochir. Suppl. · Jan 2011
Association of apolipoprotein E polymorphisms with cerebral vasospasm after spontaneous subarachnoid hemorrhage.
Cerebral vasospasm (CVS) is the main complication of spontaneous subarachnoid hemorrhage (SAH), severely affecting clinical outcome of patients with SAH. Apolipoprotein E gene (APOE) is associated with prognosis of spontaneous subarachnoid hemorrhage (SAH), and APOEε4 allele is reported to be apt to CVS after SAH. The current study aimed to investigate the association of APOE polymorphisms with CVS after SAH. ⋯ Logistic regression analysis demonstrated that ApoEε4 allele was a risk factor (OR=2.842. 95% CI 1.072-6.124. P=0.019) to predispose to CVS after adjusting for age, sex, hypertension or not, hyperlipemia or not, Fisher grade, and Hunt-Hess grade after SAH. Our finding suggests that the patients with APOEε4 allele predispose to CVS after spontaneous SAH.
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Acta Neurochir. Suppl. · Jan 2011
Analysis on death-associated factors of patients with subarachnoid hemorrhage during hospitalization.
The prognosis of patients with high-clinical-score subarachnoid hemorrhage remains poor, with early high mortality rate. Therefore, to predict the early outcome of patients after subarachnoid hemorrhage, several clinical factors were hypothesized to be related to death during hospitalization. ⋯ Increased white blood cell count may indicate poor outcomes for patients during hospitalization, even early death.