Acta neurochirurgica. Supplement
-
This manuscript describes the development and ongoing integration of neuroArm, an image-guided MR-compatible robot. ⋯ NeuroArm successfully united the precision and accuracy of robotics with the executive decision-making capability of the surgeon.
-
Acta Neurochir. Suppl. · Jan 2011
Fever increased in-hospital mortality after subarachnoid hemorrhage.
Fever is a common clinical complication in patients with subarachnoid hemorrhage (SAH), and is usually related to prognosis in early stage of diseases. In our study, we try to help improve the outcome of SAH by assessing possible risk factors for fever and investigating the influence of fever on in-hospital mortality. ⋯ Poor Hunt-Hess grade, presence of IVH and older age are independent predictors of fever in SAH. Fever is closely related to increased in-hospital mortality after SAH.
-
In recent years the quality of ultrasound (US) imaging has improved considerably. The integration of three dimensional (3D) US with neuronavigation technology has created an efficient and inexpensive tool for intra-operative imaging in neurosurgery. Our experience is based on more than 900 operations with the intra-operative 3D ultrasound equipment SonoWand® and some operations with the research equipment Custux X. ⋯ Compared to intraoperative magnetic resonance imaging (ioMRI), 3D US technology is advantageous in different ways: it is flexible and can be used in any operation theatre. There is no need for special instruments, and no need for radiologists or technicians. It adds very little extra time to the operation, and the investment-costs are considerably lower than for ioMRI.
-
Acta Neurochir. Suppl. · Jan 2011
Association of apolipoprotein E polymorphisms with cerebral vasospasm after spontaneous subarachnoid hemorrhage.
Cerebral vasospasm (CVS) is the main complication of spontaneous subarachnoid hemorrhage (SAH), severely affecting clinical outcome of patients with SAH. Apolipoprotein E gene (APOE) is associated with prognosis of spontaneous subarachnoid hemorrhage (SAH), and APOEε4 allele is reported to be apt to CVS after SAH. The current study aimed to investigate the association of APOE polymorphisms with CVS after SAH. ⋯ Logistic regression analysis demonstrated that ApoEε4 allele was a risk factor (OR=2.842. 95% CI 1.072-6.124. P=0.019) to predispose to CVS after adjusting for age, sex, hypertension or not, hyperlipemia or not, Fisher grade, and Hunt-Hess grade after SAH. Our finding suggests that the patients with APOEε4 allele predispose to CVS after spontaneous SAH.
-
Acta Neurochir. Suppl. · Jan 2011
Thrombin preconditioning reduces iron-induced brain swelling and brain atrophy.
Cerebral preconditioning with a low dose of thrombin attenuates brain edema induced by intracerebral hemorrhage (ICH), a large dose of thrombin or iron. This study examined whether or not thrombin preconditioning (TPC) reduces neuronal death and brain atrophy caused by iron. The right hippocampus of rats was pretreated with or without thrombin, and iron was then injected into the same location 3 days later. ⋯ We found that TPC reduced neuronal death and brain swelling in the hippocampus 1 day after iron injection, and hippocampal atrophy 7 days later. Western blots showed that thrombin activates p44/42 mitogen-activated protein kinase (p44/42 MAPK) and 70-kDa ribosomal protein S6 kinase (p70 S6K). Our results indicate that TPC reduction of iron-induced neuronal death may be through the p44/42 MAPK /p70 S6K signal transduction pathway.