Läkartidningen
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Tobacco smokers suffer from postoperative complications after surgery more often than non-smokers. This has been proven in both general, orthopaedic and plastic surgery. In recent years, preoperative smoking cessation has been evaluated in several studies. ⋯ There is also lacking evidence on smoking cessation in emergency surgery, and the cost-effectiveness of a smoking cessation intervention programme. Therefore, further studies on preoperative smoking cessation are needed. Three randomised multi-center trials in greater Stockholm are planned to further elucidate these questions.
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Thrombolysis is a highly promising treatment in acute ischaemic stroke. There is evidence of positive effects at least up to three hours and most probably up to six. ⋯ There is not enough evidence to answer several questions regarding the influence of patient- and stroke characteristics on effectsize; death; and risk of intracranial haemorrhage. Giving priority to new large randomized controlled trials is essential to achieve this knowledge.