Duodecim; lääketieteellinen aikakauskirja
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We describe a prolonged and successful in-hospital resuscitation, during which the cause of cardiac arrest was treated by transluminal coronary angioplasty. A closed cardiac massage device was used in the resuscitation of the patient, and the treatment required close collaboration between the cardiologist and the resuscitation team. In spite of the difficult initial situation and several disturbances of vital functions the patient was discharged in good condition.
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Gleason grading of tumor biopses is the only method to distinguish clinically significant prostate cancer. Local cancer is usually symptomless, and men would benefit from functional screening. ⋯ In blood test diagnostics, established use is made only of the levels of prostate-specific antigen (PSA) and free PSA. New methods for blood test diagnosis are "Prostate Health Index" and the four-kallikrein panel.
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Powerful resuscitation may save the life of a person having cardiac arrest. Resuscitation measures may, however, cause injuries as well. We describe a patient, in whom a perforation of the gastric wall as a complication of resuscitation was detected, and upon imaging of the perforation, renal cell carcinoma was detected as an incidental finding. The resuscitation was successful, and the complication of resuscitation led to early diagnosis and treatment of the cancer.
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Endometrial ablation is a commonly used procedure in the treatment of heavy menstrual bleeding. The procedure is considered quite safe, but may also involve severe complications. We present a patient who developed life-threatening sepsis after the procedure.
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For more than a quarter century, the research of and drug development for Alzheimer's diseases have been governed by the amyloid plaque hypothesis, whereby deranged metabolism of the amyloid precursor protein leads to the formation of extracellular amyloid plaques, which in turn causes the activation of microglial cells, destruction of neurons and a progressive memory disease. The ending of three extensive clinical trials in disappointment has raised the question whether the amyloid plaque hypothesis is the correct starting point in the development of curative treatment for Alzheimer's disease at all. Two commencing new trials with patients that are still symptomless will be the final challenge for the hypothesis.