Nihon rinsho. Japanese journal of clinical medicine
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Non-opioid analgesics such as NSAIDs play a central role for patients with cancer pain as well as for those with acute pain. Pain management using non-opioid analgesics need to avoid potential side effects, and the analgesic action of NSAIDs, cyclooxygenase inhibitors, would synergistically potentiate opioids' effects via the activation of the periaquaductal grey of the midbrain. ⋯ Undertreatment of pain is a persistent clinical problem for patients with cancer. Although changing medical practice is difficult and improving pain management with the rational use of combination of drugs may especially difficult, supplementation of non-opioid analgesics for opioid treatment would provide a better quality of life of cancer patients.
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The WHO guidelines have much improved cancer pain management in Japan. In 1987, the Ministry of Health established new policy on palliative care, revised narcotics control measures, and edited guidelines on palliative care. ⋯ In order to further achieve program implementation, educational approach should be much more strengthened. It is also emphasized that each health care professional should recognize the ethics in pain relief and each hospital should urgently has its policy to achieve freedom from cancer pain for all throughout Japan.
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This article presents the current management of acute pain(posttraumatic and postoperative pain). The management of acute pain, especially postoperative pain, makes a great advance in this twenty years. The discovery of physiology and pharmacology of pain mechanisms made a great contribution to the improvement of the patient care during postoperative period. ⋯ So these days postoperative pain, the major complaint during the postoperative period, is almost improved at the hospital that coordinates pain treatment strategies. The management of pain improves the quality of life for the postoperative patients and the prognosis of postoperative patients. We should take our warning to heart that the management of acute pain(postoperative, posttraumatic, and labor pain) is not only 'procedure' but also 'therapy' against the pain.
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Oral route morphine should be first choice for moderate or strong cancer pain. Morphine must be administered essentially at fixed interval. It is important to keep effective plasma morphine concentration. ⋯ Respiratory rate per minute of patients always must be measured during administration of morphine. Patients taking morphine have to take laxatives and antiemetics simultaneously. It is crucial to establish the cause of pain and choose other proper treatment when morphine is not effective.
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Local and regional analgesia, achieved by injecting a local anesthetic into tissues, or in proximity to certain parts of the peripheral nervous system, or into the epidural/subarachnoid space, to relieve pain has been used widely for many years. While nerve blocks no longer have the preeminent role as the pain management in cancer patients, they will remain useful tools in managing pain and increasing 'quality of life' of the cancer patients, only if they properly applied. The purpose of this chapter is to present an updated version of the regional analgesia in cancer pain management.