Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
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Zhongguo Wei Zhong Bing Ji Jiu Yi Xue · May 2007
[Effects of granulocyte-macrophage colony stimulating factor on nuclear factor-KappaB activation in multiple organs of hemorrhage-induced acute lung injury in mice].
To investigate the effects of nuclear factor-KappaB (NF-KappaB) activation in multiple organs of hemorrhage-induced acute lung injury (ALI) by the specific granulocyte-macrophage colony stimulating factor (GM-CSF)-neutralizing antibody (22E9) and dexamethasone (DEX) in mice. ⋯ 22E9 can inhibit the NF-KappaB activation and inflammatory reaction in multiple organs after hemorrhage-induced ALI and reduce injury in multiple organs, while DEX has no significant effect.
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Zhongguo Wei Zhong Bing Ji Jiu Yi Xue · May 2007
[Effects of different means of fluid resuscitation on the activity of nuclear factor-KappaB in peripheral blood mononuclear cells in rats with hemorrhagic shock].
To observe the effects of different means of fluid resuscitation on the activity of nuclear factor-KappaB (NF-KappaB) in peripheral blood mononuclear cells (PBMC) in rats with hemorrhagic shock. ⋯ The results of our study demonstrate that the limited fluid resuscitation during hemorrhagic shock could raise the 72-hour survival rate and prolong survival time. The poor prognosis of hemorrhagic shock was associated with high NF-KappaB activity in PBMC, which could be lowered with limited fluid resuscitation.