Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
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Zhongguo Wei Zhong Bing Ji Jiu Yi Xue · Sep 2008
[The potential role of high mobility group box 1 protein in immune dysfunction and its regulatory mechanism after major trauma].
To investigate the potential effect of high mobility group box 1 protein (HMGB1) on host immune response and its molecular regulation mechanism as well as its interventional pathway following major burns/trauma. ⋯ These data proved that HMGB1 not only acts as a novel "late" inflammatory mediator but is also closely associated with immunosuppression after acute insults. HMGB1 might play an important role in inducing systemic inflammatory response together with host immunological dissonance, resulting in the development of septic complications. Intervention of HMGB1 expression and release presumably provides a potentially effective way to regulate both excessive inflammatory and immune response, thereby as a measure to improve the prognosis of severe sepsis secondary to major trauma.
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Zhongguo Wei Zhong Bing Ji Jiu Yi Xue · Sep 2008
[Effect of treatment with anti-receptor for advanced glycation end products antibody on multiple organ dysfunction and mortality in rats after severe thermal injury].
To observe the effect of treatment with anti-receptor for advanced glycation end products (RAGE) antibody on multiple organ dysfunction and mortality in rats after severe burn injury, and investigate the mechanisms underlying its protective effect. ⋯ Anti-RAGE antibody could obviously improve the survival in rats with burn injury with delayed resuscitation, and it seems to be able to prevent the development of multiple organ dysfunction secondary to severe burns.