Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
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Zhongguo Wei Zhong Bing Ji Jiu Yi Xue · Apr 2012
[Effect of Xuebijing injection on rabbits ischemia/reperfusion injury induced by femoral arterial disease].
To investigate the changes in serum malondialdehyde (MDA), interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), aspartate aminotransferase (AST) and creatinine (Cr) after the reproduction of ischemia/reperfusion (I/R) injury model, and the protective effects of liver and kidney with Xuebijing injection on acute I/R injury in rabbits. ⋯ It is demonstrated that I/R injury could dramatically lead to systemic inflammatory response and oxygen free radical injury. Xuebijing injection in higher dosage can reduce the systemic inflammatory response significantly, and also MDA level in serum. Xuebijing injection in low dosage, middle dosage and high dosage can produce protective effects against the damages to liver and kidney function.