Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
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Zhongguo Wei Zhong Bing Ji Jiu Yi Xue · Jan 2009
[Study of the role of endoplasmic reticulum stress mediated apoptosis signal pathway in sepsis-induced splenic lymphocyte apoptosis].
To investigate the role of endoplasmic reticulum (ER) stress-mediated apoptosis signal pathway in extensive apoptosis of splenic lymphocytes in sepsis. ⋯ These results demonstrates activation of the ER stress response in lymphocytes and that ER stress may contribute to abnormal lymphocyte apoptosis during sepsis.
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Zhongguo Wei Zhong Bing Ji Jiu Yi Xue · Jan 2009
[Evaluation of compliance with bundle treatment in the management of severe infection].
To evaluate compliance with bundle treatment in the management of severe infection in a tertiary hospital, aiming at analyzing clinical data in order to popularize guidelines for management of severe sepsis and septic shock. ⋯ Bundle treatment for severe infection is complied with partially in our hospital, suggesting that it is still quite arduous to popularize guidelines for management of severe sepsis and septic shock in our country.
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Zhongguo Wei Zhong Bing Ji Jiu Yi Xue · Jan 2009
[Characteristics and treatment of multiple organ dysfunction syndrome in patients with trauma in the Wenchuan earthquake on 12th May, 2008].
To analyze the characteristics and treatment of the multiple organ dysfunction syndrome (MODS) in patients in the Wenchuan earthquake on 12th May, 2008, in order to provide theoretical reference for future care for such patients. ⋯ Fracture of bones of extremities are predominant injury in the earthquake related diseases, and the cause of death is closely associated with multiple trauma and ARF, systemic infection of large wound surfaces. The central nervous system, respiratory system, circulatory system, renal function, circulatory system should be monitored during the treatment. Adequate preparedness is essential in order to cope with the peak period of occurrence of serious complications after a disaster.
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Zhongguo Wei Zhong Bing Ji Jiu Yi Xue · Jan 2009
[Changes in adrenal cortex function and protective effect of dexamethasone in septic rats during early phases].
To affirm the presence of relative adrenal insufficiency (RAI) in the early phases of sepsis and its probable mechanisms, and to study the optimal time for glucocorticoid replacement therapy. ⋯ (1)RAI occurs during the early stage of sepsis. (2)The expressions of TLR4, TNF-alpha mRNA in adrenal and changes in corticoadrenal ultrastructure participates in the pathogenesis of RAI in the early stage of sepsis in rat. (3) Dexamethasone therapy could effectively increase the survival rate and improve outcome through down-regulating the expression changes in TLR4, TNF-alpha mRNA and alleviating changes in ultrastructure of adrenal glands. Early administration of dexamethasone may give good result in the treatment of sepsis.