Polskie Archiwum Medycyny Wewnętrznej
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Pol. Arch. Med. Wewn. · Sep 2021
Comparison of coronary flow reserve feasibility in different stress echocardiography protocols: dobutamine, dipyridamole, exercise and rapid pacing.
The assessment of coronary flow velocity reserve (CFVR) may improve the diagnostic and prognostic value of stress echocardiography (SE). ⋯ CFVR in the LAD can be obtained during all forms of SE, but the feasibility is significantly higher with rapid cardiac pacing and pharmacological tests as compared with exercise, which was identified in our study as an independent predictor of the loss of blood flow during a blood flow recording in the LAD at the peak of stress test.
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Pol. Arch. Med. Wewn. · Sep 2021
Dehydroepiandrosterone sulfate indicates decreased sulfation capacity and impaired quality of life in patients with primary sclerosing cholangitis.
Impaired elimination of toxic compounds via inadequate sulfation may contribute to the pathogenesis of primary sclerosing cholangitis (PSC). Dehydroepiandrosterone (DHEA), which is metabolized into its sulfated form (DHEA-S) in the liver, has been linked with health-related quality of life (HRQoL) in various conditions. ⋯ Our findings support the role of impaired liver sulfation capacity in the development of PSC. Low levels of DHEA-S are associated with increased fatigue, a devastating symptom significantly affecting HRQoL. Thus, the effects of DHEA administration on chronic fatigue and other measures of HRQoL in patients with PSC warrant further attention.