Polskie Archiwum Medycyny Wewnętrznej
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Pol. Arch. Med. Wewn. · Mar 2023
POL-RISK: an algorithm for 10-year fracture risk prediction in the postmenopausal women from the RAC-OST-POL Study.
Fragility fractures are the major consequence of osteoporosis. Thus, fracture risk assessment is an essential part of the diagnostic process in osteoporosis. ⋯ A fracture prediction algorithm was developed in a longitudinal study to enable calculation of the 10‑year fracture risk. Identification of patients at a high risk of fracture should be followed by implementation of appropriate treatment strategy to reduce the number of future fractures.
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Pol. Arch. Med. Wewn. · Mar 2023
Clinical TrialAn influence of elevated heart rate by automated office blood pressure measurement on cardiovascular events risk.
The predictive value of heart rate (HR) assessed using an automated office blood pressure measurement (AOBPM) remains unknown. ⋯ High AOBPM HR is associated with a higher risk of cardiovascular events and mortality, whereas low HR may result in higher MI risk in patients with previous CVD.
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Pol. Arch. Med. Wewn. · Mar 2023
Effectiveness of pangenotypic retreatment of chronic hepatitis C after prior failure of pangenotypic therapies.
Despite the overall excellent efficacy of pangenotypic direct‑acting antiviral (DAA) options, there is still a small percentage of patients with hepatitis C virus (HCV) infection who do not respond to the therapy. ⋯ Our study demonstrated the excellent effectiveness of pangenotypic regimens and confirmed that most DAA nonresponders could be successfully retreated with another pangenotypic regimen. The best retreatment strategy is a triple pangenotypic regimen, especially in patients with unfavorable response factors, such as genotype 3 infection, cirrhosis, and male sex.