TheScientificWorldJournal
-
TheScientificWorldJournal · Jan 2014
ReviewA review of intraoperative goal-directed therapy using arterial waveform analysis for assessment of cardiac output.
Increasing evidence shows that goal-directed hemodynamic management can improve outcomes in surgical and intensive care settings. Arterial waveform analysis is one of the different techniques used for guiding goal-directed therapy. ⋯ Although small-scale clinical trials using these monitors show promising data, large-scale multicenter trials are still needed to better determine how intraoperative goal-directed therapy with arterial waveform analysis can improve patient outcomes. This review provides a comparative analysis of the different arterial waveform monitors for intraoperative goal-directed therapy.
-
TheScientificWorldJournal · Jan 2014
ReviewFault location based on synchronized measurements: a comprehensive survey.
This paper presents a comprehensive survey on transmission and distribution fault location algorithms that utilize synchronized measurements. Algorithms based on two-end synchronized measurements and fault location algorithms on three-terminal and multiterminal lines are reviewed. Series capacitors equipped with metal oxide varistors (MOVs), when set on a transmission line, create certain problems for line fault locators and, therefore, fault location on series-compensated lines is discussed. ⋯ Work associated with fault location on power system networks, although limited, is also summarized. Additionally, the nonstandard high-frequency-related fault location techniques based on wavelet transform are discussed. Finally, the paper highlights the area for future research.
-
TheScientificWorldJournal · Jan 2014
ReviewA hypothesis: hydrogen sulfide might be neuroprotective against subarachnoid hemorrhage induced brain injury.
Gases such as nitric oxide (NO) and carbon monoxide (CO) play important roles both in normal physiology and in disease. Recent studies have shown that hydrogen sulfide (H2S) protects neurons against oxidative stress and ischemia-reperfusion injury and attenuates lipopolysaccharides (LPS) induced neuroinflammation in microglia, exhibiting anti-inflammatory and antiapoptotic activities. ⋯ It has been known that multiple factors, including oxidative stress, free radicals, and neuronal nitric oxide synthesis as well as abnormal inflammatory responses, are involved in the mechanism underlying the brain injury after subarachnoid hemorrhage (SAH). Based on the multiple physiologic functions of H2S, we speculate that it might be a promising, effective, and specific therapy for brain injury after SAH.
-
TheScientificWorldJournal · Jan 2014
Randomized Controlled TrialNoninvasive techniques for blood pressure measurement are not a reliable alternative to direct measurement: a randomized crossover trial in ICU.
Noninvasive blood pressure (NIBP) monitoring methods are widely used in critically ill patients despite poor evidence of their accuracy. The erroneous interpretations of blood pressure (BP) may lead to clinical errors. ⋯ BP measurements with different devices produced significantly different results. Since in critically ill patients the importance of BP readings is often crucial, noninvasive techniques cannot be regarded as reliable alternatives to direct measurements.
-
TheScientificWorldJournal · Jan 2014
ReviewMolecular alterations of PI3K/Akt/mTOR pathway: a therapeutic target in endometrial cancer.
It is well established that the PI3K/Akt/mTOR pathway plays a central role in cell growth and proliferation. It has also been suggested that its deregulation is associated with cancer. ⋯ This paper reviews alterations in the PI3K/Akt pathway, which could possibly contribute to the development of endometrial cancer. In addition, potential therapeutic targets of this pathway with emphasis on the mTOR inhibitors are also presented.