Regional anesthesia
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Regional anesthesia · Sep 1993
Local myotoxicity of bupivacaine in rabbits after continuous supraclavicular brachial plexus block.
Local anesthetics including bupivacaine have been known to be myotoxic. Continuous brachial plexus blocks with bupivacaine provide good postoperative pain relief, but their effects on the surrounding muscles have not been studied. ⋯ Brachial plexus blocks with bupivacaine caused reversible myotoxicity and inflammation in the rabbit. A week after the continuous blocks, muscle fiber regeneration had already started.