Regional anesthesia
The most recent articles from:
Reg Anesth
-
Regional anesthesia · Nov 1996
Letter Biography Historical ArticleTorrieri and combined spinal-epidural technique.
-
Regional anesthesia · Sep 1996
Subarachnoid bupivacaine increases human cerebrospinal fluid concentration of serotonin.
Serotonin (5-hydroxytryptamine [5-HT]) has antinociceptive properties at the spinal level. Activation of descending serotonergic neurons or topically applied 5-HT at the spinal cord inhibits rostral spread of sensory information. Epidural anesthesia has been shown to increase 5-HT in plasma, and local anesthetics may interfere with 5-HT reuptake and metabolism. For these reasons, the action of subarachnoid local anesthetics on cerebrospinal fluid (CSF) 5-HT concentrations has been studied. ⋯ Subarachnoid bupivacaine increases local 5-HT concentration. This may have implications for nociceptive gating as well as for local vasoregulation.