Casopís lékar̆ů c̆eských
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Casopís lékar̆ů c̆eských · Jan 2008
[Experience with early enteral nutrition application in critically ill patients in medical intensive care unit].
Early enteral nutrition is recommended in patients with critical illness. Generally implementing of nutritional support algorithm is advised. The aim of study was evaluation of early enteral nutrition application in critically ill patients in medical intensive care unit. ⋯ Early enteral nutrition applied according to protocol was given succesfully to the substantial number of the critical patients. In 18% of the patients enteral nutrition had to be replaced for parenteral one due to complications. The caloric intake 25-30 calories/kg was reached in 60% of patients.
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Casopís lékar̆ů c̆eských · Jan 2008
Historical Article[Rationality and irrationality in the medicine and in the life].
The spiritual life of man has a rational and irrational component. Both have positive as well as negative effects and under normal circumstances they are well balanced. In medicine rationality is an essential feature of the medical science and the basis of medical practice but it is not sufficient for fulfilling all curative needs. In the practice, gaps in knowledge must be complemented by empiricism and empathy which originate in the personality of the physician.
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Casopís lékar̆ů c̆eských · Jan 2008
[Decrease of the prevalence of Helicobacter pylori infection in the Czech Republic].
Helicobacter pylori (Hp) is the most common chronic bacterial infection in humans. Hp has been demonstrated worldwide and in individuals of all ages. ⋯ This decrease can be explained mostly by the relatively favourable and improving socioeconomic conditions after the fall of communist regime. However, it is necessary to consider also the fundamental determinants of "modern times" that could cause gradual disappearing of Hp from the human "microbiome".
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Casopís lékar̆ů c̆eských · Jan 2007
Randomized Controlled Trial Comparative Study[Pilot study to evaluate blood glucose control by a model predictive control algorithm with variable sampling rate vs. routine glucose management protocol in peri- and postoperative period in cardiac surgery patients].
Increased blood glucose levels are frequently observed in critically ill patients. Recent studies have shown that the normalization of glycemia by intensive insulin therapy decreases mortality, length of the hospitalization and number of complications. ⋯ The results of our pilot study suggest that eMPC algorithm is more effective in maintaining euglycemia in peri- and post-operative period in patients after cardiac surgery and comparably safe as compared to RP.
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Polymorphisms in drug metabolizing enzymes are considered as a major factor influencing the incidence of adverse drug reactions or failure of pharmacotherapy. Our aim was to compare the distribution of functional polymorphisms in the genes CYP2D6 and CYP2C19 between healthy control group and of patients reffered to our department due to adverse drug reactions or insufficient efficacy of a treatment. ⋯ Clinically apparent alteration of drug effects are often caused by partial or complete deficit of CYP2D6 activity. Our results confirm the importance of CYP2D6 polymorphisms on the efficycy and safety of pharmacotherapy.