The lancet. Diabetes & endocrinology
-
Lancet Diabetes Endocrinol · Apr 2015
Review Meta AnalysisEffects of RAS inhibitors on diabetic retinopathy: a systematic review and meta-analysis.
Results of several studies have shown a possible beneficial effect of renin-angiotensin system (RAS) inhibitors on diabetic retinopathy, but the findings were contradictory. We did a systematic review and meta-analysis to assess the effect of RAS inhibitors on diabetic retinopathy. ⋯ In patients with diabetes, RAS inhibitors reduce the risk of diabetic retinopathy, and increase the possibility of diabetic retinopathy regression. ACE inhibitors might be better than ARBs for treating diabetic retinopathy, and might exert the most beneficial effect on diabetic retinopathy of all widely used antihypertensive drug classes.
-
Lancet Diabetes Endocrinol · Mar 2015
Review Meta Analysis Historical ArticleRisk of all-cause mortality and vascular events in women versus men with type 1 diabetes: a systematic review and meta-analysis.
Studies have suggested sex differences in the mortality rate associated with type 1 diabetes. We did a meta-analysis to provide reliable estimates of any sex differences in the effect of type 1 diabetes on risk of all-cause mortality and cause-specific outcomes. ⋯ None.
-
Lancet Diabetes Endocrinol · Jan 2015
Meta AnalysisLong working hours, socioeconomic status, and the risk of incident type 2 diabetes: a meta-analysis of published and unpublished data from 222 120 individuals.
Working long hours might have adverse health effects, but whether this is true for all socioeconomic status groups is unclear. In this meta-analysis stratified by socioeconomic status, we investigated the role of long working hours as a risk factor for type 2 diabetes. ⋯ Medical Research Council, European Union New and Emerging Risks in Occupational Safety and Health research programme, Finnish Work Environment Fund, Swedish Research Council for Working Life and Social Research, German Social Accident Insurance, Danish National Research Centre for the Working Environment, Academy of Finland, Ministry of Social Affairs and Employment (Netherlands), Economic and Social Research Council, US National Institutes of Health, and British Heart Foundation.
-
Lancet Diabetes Endocrinol · Sep 2014
Meta AnalysisAssociation of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study.
Low plasma 25-hydroxyvitamin D (25[OH]D) concentration is associated with high arterial blood pressure and hypertension risk, but whether this association is causal is unknown. We used a mendelian randomisation approach to test whether 25(OH)D concentration is causally associated with blood pressure and hypertension risk. ⋯ British Heart Foundation, UK Medical Research Council, and Academy of Finland.
-
Lancet Diabetes Endocrinol · Aug 2014
Review Meta AnalysisCardiovascular disease, chronic kidney disease, and diabetes mortality burden of cardiometabolic risk factors from 1980 to 2010: a comparative risk assessment.
High blood pressure, blood glucose, serum cholesterol, and BMI are risk factors for cardiovascular diseases and some of these factors also increase the risk of chronic kidney disease and diabetes. We estimated mortality from cardiovascular diseases, chronic kidney disease, and diabetes that was attributable to these four cardiometabolic risk factors for all countries and regions from 1980 to 2010. ⋯ UK Medical Research Council, US National Institutes of Health.