Archives of pediatrics & adolescent medicine
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Arch Pediatr Adolesc Med · Sep 2011
Randomized Controlled Trial Multicenter Study Comparative StudyComparative efficacy and safety of 4 randomized regimens to treat early Pseudomonas aeruginosa infection in children with cystic fibrosis.
To investigate the efficacy and safety of 4 antipseudomonal treatments in children with cystic fibrosis with recently acquired Pseudomonas aeruginosa infection. ⋯ No difference in the rate of exacerbation or prevalence of P aeruginosa positivity was detected between cycled and culture-based therapies. Adding ciprofloxacin produced no benefits.
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Arch Pediatr Adolesc Med · Sep 2011
Randomized Controlled Trial Comparative StudyEfficient intravenous access without distress: a double-blind randomized study of midazolam and nitrous oxide in children and adolescents.
To determine whether treatment with midazolam or with nitrous oxide is more efficient in facilitating intravenous (IV) access in lean and obese children and adolescents. ⋯ Compared with treatment with midazolam, treatment with 50% nitrous oxide during IV line procedures results in a shorter total procedure time, improved rate of IV access, and a better experience for the child or adolescent. Only under rare circumstances should obese children or adolescents be treated with midazolam because of the long procedure time.
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Arch Pediatr Adolesc Med · Sep 2011
Randomized Controlled TrialPaternal vs maternal kangaroo care for procedural pain in preterm neonates: a randomized crossover trial.
To test paternal vs maternal kangaroo care (KC) to reduce pain from heel lance. ⋯ Mothers were marginally more effective than fathers in decreasing pain response. Future research should address feasibility issues and nonparent providers of KC during painful procedures.
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Arch Pediatr Adolesc Med · Aug 2011
Randomized Controlled Trial Multicenter StudyWhole-body hypothermia for term and near-term newborns with hypoxic-ischemic encephalopathy: a randomized controlled trial.
To determine the effectiveness and safety of moderate whole-body hypothermia in newborns with hypoxic-ischemic encephalopathy born in hospitals with and without newborn intensive care facilities or complicated hypothermia equipment. ⋯ Whole-body hypothermia is effective and appears to be safe when commenced within 6 hours of birth at the hospital of birth in term and near-term newborns with hypoxic-ischemic encephalopathy. This simple method of hypothermia could be used within strict protocols with appropriate training on correct diagnosis and application of hypothermia in nontertiary neonatal settings while awaiting retrieval and transport to the regional neonatal intensive care unit.
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Arch Pediatr Adolesc Med · Aug 2011
Randomized Controlled Trial Comparative StudyA randomized trial of air cleaners and a health coach to improve indoor air quality for inner-city children with asthma and secondhand smoke exposure.
To test an air cleaner and health coach intervention to reduce secondhand smoke exposure compared with air cleaners alone or no air cleaners in reducing particulate matter (PM), air nicotine, and urine cotinine concentrations and increasing symptom-free days in children with asthma residing with a smoker. ⋯ Although the use of air cleaners can result in a significant reduction in indoor PM concentrations and a significant increase in symptom-free days, it is not enough to prevent exposure to secondhand smoke.